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Endosulfan is a ubiquitous environmental contaminant. The chemical is semivolatile and persistent to degradation processes in the environment.
Endosulfan is subject to long-range atmospheric transport, i.e.
EPA's acute reference dose for dietary exposure to endosulfan is 0.015 mg/kg for adults and 0.0015 mg/kg for children.
For chronic dietary expsoure, the EPA references doses are 0.006 mg/(kg·day) and 0.0006 mg/(kg·day) for adults and children, respectively.
The two isomers, endo and exo, are known popularly as I and II.
and both the EPA and the Agency for Toxic Substances and Disease Registry consider endosulfan to be a potential endocrine disruptor.
Numerous in vitro studies have documented its potential to disrupt hormones and animal studies have demonstrated its reproductive and developmental toxicity, especially among males.
It is produced by Makhteshim Agan and several manufacturers in India and China.
Although, the Supreme Court had, by an order dated , put a ban on the production and sale of endosulfan in India till further orders.